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Nonmalignant, chronic pain is associated with physical, emotional and financial disability.Recent animal studies have shown that remodeling within the central nervous system causes the physical pathogenesis of chronic pain.Anecdotally, dextromethorphan, an -methyl-D-aspartate (NMDA) receptor antagonist available as an over-the-counter (OTC) antitussive, is beneficial as adjunctive therapy in patients with fibromyalgia.
Benzodiazepines can impair the ability to drive or operate machinery and may thus interfere with essential activities of daily living.
They lower the tolerance to alcohol and are widely reported to cause physical and psychological dependence and withdrawal symptoms.
Lavender flower and its extracts have been used, both internally and by olfaction, for centuries as a treatment for anxiety and depression.
Modern analytical research has identified the main active constituents of the oil; in vitro and animal studies have begun to elucidate mechanisms of action; and controlled clinical trials in humans now document lavender’s efficacy, safety, and dose.
This mixture of physical, emotional and social abnormalities often complicates managing patients with chronic pain.